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Since it prevents lactation, cabergoline should not be administered to mothers with hyperprolactinemic disorders who wish to breast-feed their infants. Patients should be careful when performing actions which require fast and accurate reaction during treatment initiation. During the first days of cabergoline administration, patients should be cautioned about re-engaging in activities requiring rapid and precise responses such as driving an automobile or operating machinery, sustaviron 250 mg injectable steroids $42.00 sustanon (testosterone blend). Patients being treated with cabergoline and presenting with somnolence must be informed to refrain from driving or engaging in activities where impaired alertness may put themselves and others at risk of serious injury or death (e. Adverse events are generally dose-related. In patients known to be intolerant to dopaminergic drugs, the likelihood of adverse events may be lessened by starting therapy with cabergoline at reduced doses, e. If persistent or severe adverse events occur, temporary reduction of dosage followed by a more gradual increase, e. The following undesirable effects have been observed and reported during treatment with cabergoline with the following frequencies: Very common (?1/10); common (?1/100 to 14 C]-cabergoline: a rapid and extensive biotransformation of cabergoline was shown. The low urinary excretion of unchanged cabergoline has been confirmed also in studies with non-radioactive product. The elimination half-life of cabergoline, estimated from urinary excretion rates, is long (63-68 hours in healthy volunteers (using a radio-immuno assay), 79-115 hours in hyperprolactinaemic patients (using a HPLC method). On the basis of the elimination half-life, steady state conditions should be achieved after 4 weeks, as confirmed by the mean peak plasma levels of cabergoline obtained after a single dose (37 ‘ 8 pg/ml) and after a 4 week multiple regimen (101 ‘ 43 pg/ml). In vitro experiments showed that the drug at concentrations of 0. Food does not appear to affect absorption and disposition of cabergoline. There were maternotoxic effects but no teratogenic effects in mice given cabergoline at doses up to 8 mg/kg/day (approximately 55 times the maximum recommended human dose) during the period of organogenesis. A dose of 0. These losses could be due to the prolactin inhibitory properties of cabergoline in rats. At daily doses of 0. Doses of 4 mg/kg/day (approximately 150 times the maximum recommended human dose) during the period of organogenesis in the rabbit caused an increased occurrence of various malformations. However, in another study in rabbits, no treatment-related malformations or embryofoetotoxicity were observed at doses up to 8 mg/kg/day (approximately 300 times the maximum recommended human dose). Medically reviewed by Drugs. Last updated on June 28, 2020. Note: This document contains side effect information about cabergoline. 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