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Corticosteroids have different therapeutic uses: Anti-inflammatory : The drugs act on the immune system by blocking the production of substances that trigger inflammation, such as prostaglandins. This can help rapidly relieve redness, warmth, swelling, and pain either locally (in a specific area) or systemically (throughout the entire body). Immunosuppressive : Corticosteroids can suppress the action of the immune system when it acts against it (such as occurs with autoimmune diseases) by impairing the production of defensive white blood cells, called T cells. Vasoconstrictive : The drugs block an inflammatory compound called histidine and, by doing so, can reduce mucus secretions that can congest airways and other organs. Among them: System/Category Disease Blood Hemolytic anemia Leukemia Lymphoma Multiple myeloma Endocrine Addison’s disease Congenital adrenal hyperplasia Eyes Optic neuritis Keratoconjunctivitis Uveitis Gastrointestinal Autoimmune hepatitis Crohn’s disease Ulcerative colitis Joints Osteoarthritis Septic arthritis Tendinosis Respiratory Allergic rhinitis Anaphylaxis Asthma Chronic obstructive pulmonary disease (COPD) Cystic fibrosis (CF) Nasal polyps Pulmonary sarcoidosis Rheumatic Gout Mixed connective tissue disease (MCTD) Multiple sclerosis (MS) Polymyalgia rheumatica Polymyositis Rheumatoid arthritis Systemic lupus erythematosus Vasculitis Skin Angioedema Atopic dermatitis (eczema) Contact dermatitis Pemphigus vulgaris Scleroderma Urticaria (hives) Other Cerebral edema Chronic hepatitis Drug allergies Food allergies Nephrotic syndrome Organ transplants Prostate cancer. Corticosteroids can be delivered orally (in pill or liquid form), topically (applied to the skin or eyes), intramuscularly (by injection into a muscle), intra-articularly (by injection into a joint space), intravenously (by injection into a vein), or by inhalation (into the nose or lungs). Some of the more commonly prescribed corticosteroids are cortisone, hydrocortisone, prednisone, prednisolone, and methylprednisolone. Most corticosteroids are available by prescription only (with the exception of over-the-counter nasal sprays or topical steroids like hydrocortisone 1%). In some cases, the brand name of the drug will be the same irrespective of the route of administration; in others, the brand name can differ. Corticosteroid can cause side effects, the range of which can vary by the formulation and route of administration. Generally speaking, the side effects of oral steroids tend to be the most severe, particularly if used on a prolonged basis. If overused or administered in excessively high doses, some corticosteroids can mimic the symptoms of Cushing syndrome, an adrenal disease characterized by the overproduction of cortisol. The side effects of corticosteroids can be minimized by taking the lowest effective dose for the shortest period of time need to achieve the therapeutic goals. Never alter the prescribed dosage without first speaking with your doctor. Once exposed to a corticosteroid drug, the body will be fooled into thinking there are ample quantities of cortisol in the body and no longer produce the hormone itself. The longer you are on treatment, the more the adrenal glands will stop functioning and effectively go into hibernation. If the corticosteroid drug is suddenly discontinued, it can take a long time for the adrenal glands to start working again and meet the body’s cortisol needs. Without enough cortisol to keep the body functioning normally, an adrenal crisis can occur, manifesting with a range of potentially severe symptoms, including: Abdominal pain or flank pain Headache High fever Dizziness or lightheadedness Severe weakness Sluggish movements Excessive sweating Dehydration Fatigue Confusion Nausea or vomiting Rapid heart rate Rapid respiration rate Loss of consciousness Coma ? ? Another possible complication is steroid withdrawal syndrome in which symptoms of the treated condition suddenly return once the treatment is stopped. Although this is mainly associated with oral steroids, it can even occur when topical steroids are used for a long time. Depending on the dose and the duration of therapy, the tapering period can last anywhere from weeks to years and must be supervised by an experienced physician. A Word from Verywell, buy boldenone 300 mg injectable steroids equipoise, eq. Corticosteroids are powerful drugs that can improve symptoms of many inflammatory or autoimmune diseases. With that said, the risks may outweigh the benefits if the drugs are overused or used inappropriately. Always take corticosteroids as prescribed. If symptoms develop during treatment, let your doctor know but do not stop treatment until your doctor tells you to.
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